MP29-06 THERAPEUTIC EXPLOITATION OF THE SCHISTOSOMA HAEMATOBIUM HOMOLOG OF INTERLEUKIN-4-INDUCING PRINCIPLE OF SCHISTOSOMA MANSONI EGGS FOR CHEMOTHERAPY-INDUCED HEMORRHAGIC CYSTITIS AND BLADDER HYPERSENSITIVITY

Molecular characterization of an interleukin-4-inducing factor from Schistosoma mansoni eggs.

The eggs of the parasitic trematode Schistosoma mansoni are powerful inducers of a T helper type 2 (Th2) immune response and immunoglobulin E (IgE) production. S. mansoni egg extract (SmEA) stimulates human basophils to rapidly release large amounts of interleukin (IL)-4, the key promoter of a Th2 response. Here we show purification and sequence of the IL-4-inducing principle of S. mansoni eggs...

hestopathoglogical studies on migration of schistosoma haematobium and schistosoma mansoni larvae in laboratory animals

in this paper the histopathological observation of the migratory phase of schistosome larvae (schistosomulae) in the laboratory animal were studied. the first tissue samples were taken from the skin of infected animals 30 minutes after exposure to the cercariae and continued daily up to 40 days post infection. the tissue specimens were taken from skin, liver. lung, lymph nodes, kidney, brain, b...

In Vitro and In Vivo Activities of Arachidonic Acid against Schistosoma 1 mansoni and Schistosoma haematobium

In vitro and in vivo activities of arachidonic acid against Schistosoma mansoni and Schistosoma haematobium.

The development of arachidonic acid (ARA) for treatment of schistosomiasis is an entirely novel approach based on a breakthrough discovery in schistosome biology revealing that activation of parasite tegument-bound neutral sphingomyelinase (nSMase) by unsaturated fatty acids, such as ARA, induces exposure of parasite surface membrane antigens to antibody binding and eventual attrition of develo...

Detection of Schistosoma mansoni and Schistosoma haematobium by Real-Time PCR with High Resolution Melting Analysis

The present study describes a real-time PCR approach with high resolution melting-curve (HRM) assay developed for the detection and differentiation of Schistosoma mansoni and S. haematobium in fecal and urine samples collected from rural Yemen. The samples were screened by microscopy and PCR for the Schistosoma species infection. A pair of degenerate primers were designed targeting partial regi...